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High intensity versus intermediate intensity versus low intensity statin treatment (statins)

Last reviewed 20 Aug 2022

Dose of particular statin versus reduction in LDL cholesterol

Dose (mg/day)	5	10	20	40	80
fluvastatin	-	-	21% a	27% a	33% b
pravastatin	-	20% a	24% a	29% a	-
simvastatin	-	27% a	32% b	37% b	42% c,d
atorvastatin	-	37% b	43% c	49% c	55% c
rosuvastatin	38% b	43% c	48% c	53% c	-

a 20%- 30%: low intensity
b 31%- 40%: medium intensity
c Above 40%: high intensity
d Advice from the MHRA: there is an increased risk of myopathy associated with high-dose (80 mg) simvastatin. The 80 mg dose should be considered only in patients with severe hypercholesterolaemia and high risk of cardiovascular complications who have not achieved their treatment goals on lower doses, when the benefits are expected to outweigh the potential risks.

Reference:

NICE (July 2014). Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease

Primary prevention of coronary heart disease

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High intensity versus intermediate intensity versus low intensity statin treatment (statins)

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