Omapatrilat inhibits:
Omapatrilat was compared to lisinopril in 573 patients with NYHA grade II-IV heart failure. The patients had all required ACE inhibitor therapy prior to the trial.
Target doses were:
Follow-up was 24 weeks.
The primary endpoint was exercise tolerance measured by a treadmill test at 12 weeks. Secondary endpoints included death, admission or discontinuation of treatment because of worsening heart failure.
Reference:
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