This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages without signing in

Platelets, fibrinolytic activity and clotting factors

Authoring team

  • platelets: platelet activation and aggregation may be as a result of the rupture of an atherosclerotic plaque with exposure of subendothelial collagen. Platelet aggregation reduces coronary blood flow in three ways:
    • platelets form part of an occlusive thrombus
    • platelet microemboli may reduce perfusion
    • mediators such as thromboxane A2 may induce vasospasm Anti-platelet drugs such as aspirin are effective in prophylaxis against ischaemic heart disease.

  • fibrinolytic activity: low fibrinolytic activity is associated with the development of ischaemic heart disease in young men. This factor may exert a long-term influence by impairing the removal of fibrin deposits that contribute to atherogenesis.

  • clotting factors and fibrinogen: high levels of fibrinogen and high factor VII activity are both independently associated with an increased incidence of ischaemic heart disease.

Ref: (1) Meade TW et al.Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Sudy.Lancet (1993);324:1076- 1079.

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.