reduced maximal exercise capacity (median change in exercise time -96 s) compared with that of patients who continued to receive digoxin (change in exercise time +4.5 s) (p = 0.003)
an increased incidence of treatment failures: 39% in the digoxin withdrawal group vs. 19% in the digoxin maintenance group, p=0.039)
shorter times to treatment failure (p = 0.037)
higher body weight (p = 0.044)
higher heart rate (p = 0.003)
lower left ventricular ejection fraction (p = 0.016)
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