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Actinic prurigo

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Actinic prurigo is a rare idiopathic photodermatosis. Persistent pruritic papules or nodules may develop in covered and exposed areas, usually in the first decade. Photosensitivity may be severe. The condition may be perennial. It has been associated with the human leukocyte antigen (HLA) subtype DRB1*0407 (1).

Actinic prurigo is managed again by restriction of UVR and the use of high SPF sunscreens; PUVA or broadband UVB therapy, or low doses of thalidomide may be necessary.

Reference:

(1) Suárez A et al. Association of HLA subtype DRB1*0407 in Colombian patients with actinic prurigo. Photodermatol Photoimmunol Photomed. 2006;22(2):55-8
(2) Am J Clin Dermatol. 2002;3(4):239-46.
(3) Ferguson (1992). Photosensitivity Disorders. In Medicine International. 102.

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