An individual's environment seems to influence how likely it is that a genetic predisposition to rheumatoid arthritis is clinically expressed. For example, populations with similar or identical genotypes may not be concordant for rheumatoid arthritis:
One interesting theory is that appears to be no historical records of rheumatoid arthritis in ancient civilizations. It may be that a new extrinsic agent has arisen in the interim - for example an as yet unknown virus - that acts as a trigger in susceptible individuals.
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