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Contra-indications and warnings for methotrexate

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • pregnancy and lactation
  • gross renal or hepatic disease or high alcohol intake
  • pre-existing lung disease
  • blood dyscrasia
  • teratogenesis - stop 90 days before possible conception
  • reduced male fertility
  • care with drugs including: sulphonamides, co-trimoxazole, diuretics, azathioprine, phenytoin, NSAIDs, Trimethoprim, Probenecid

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