if non-ulcerated necrobiosis lipoidica (NL) then possible treatment measures include topical corticosteroids (e.g. application of steroid creams under occlusive dressings); also intralesional and systemic corticosteroids are possible treatment modalities (1). Topical PUVA appears to be a promising therapeutic option in the treatment of non-ulcerated NL
steroid use is beneficial to control the initial erythema in early lesions but fails to help with the atrophic component of the lesions and can worsen atrophy (2)
if ulcerated NL then there may be response to immunomodulating drugs such as cyclosporin and mycophenolate mofetil
Reference:
British Journal of Diabetes and Vascular Disease 2005; 5(1):37-41.
Duff M et al. Cutaneous Manifestations of Diabetes Mellitus.Clin Diabetes. 2015 Jan; 33(1): 40-48.
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