Psoriasis and diabetes

Diabetes has an increased prevalence in patients with psoriasis:

• reported type 2 diabetes in 18.1% of patients with psoriasis and 12.3% of control (1)
• reported that (2)
  • psoriasis is associated with diabetes independent of sex, age, smoking, and body mass index (BMI) (OR 1.53, 1.03-2.27) and that increases in BMI are associated with increasing odds of twins reporting a diagnosis of psoriasis

Genetics and diabetes and psoriasis risks:

• genetic variation at IL12B, IL23R and IL23A has an influence on the risk for Psoriasis and on disease severity and type 2 diabetes mellitus

References:

1. Bang CN et al. Psoriasis is associated with subsequent atrial fibrillation in hypertensive patients with left ventricular hypertrophy: the losartan intervention for endpoint study. J Hypertens. 2014;32(3):667-672.
2. Lonnberg AS et al.Heritability of psoriasis in a large twin sample.Br J Dermatol. 2013 Aug;169(2):412-6. doi: 10.1111/bjd.12375.
3. Eirís N, Gonzalez-Lara L, Santos-Juanes J, Queiro R, Coto E, Coto-Segura P. Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. Journal of Dermatological Science. 2014;75(3):167-172.