Sulphasalazine is metabolised by colonic bacteria and azo-reduction to produce sulpha and salicylate moities.
Most sulphapyridine is absorbed, acetylated by the liver, and excreted by the kidneys.
5-ASA is mainly excreted in the faeces after acetylation by colonic epithelium, bacteria, or the liver. Only a small proportion 5-ASA reaches the systemic circulation.
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