Differential diagnosis
TEN should be differentiated from the following exfoliating, desquamating, or blistering diseases:
- Staphylococcal scalded skin syndrome (SSSS) - blistering is more superficial and involvement of the mucous membrane is less common than in TEN
- Stevens-Johnson syndrome (SJS) - Detachment <10% of body surface with widespread purpuric or erythematous macules or both and flat atypical target lesions
- Bullous erythema multiforme - Detachment <10% of body surface area and localised target lesions or raised atypical targets
- Bullous pemphigoid
- Pemphigus
Reference:
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