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Factors associated with a higher risk of recurrence

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

There are several factors that may have an effect on recurrence rate including histological sub-type, other histological features, site, and other patient and tumour features.

Histological sub-type

  • morphoeic – linear groups of cancer cells with surrounding scarring; clinically this causes a thickened and hardened skin
  • infiltrating – like morphoeic but with less scarring
  • micronodular – very small groups of cancer cell
  • basosquamous carcinoma – a skin cancer with both basal and squamous elements

Histological features

  • perineural invasion
  • invasion below dermis

Sites

  • nose and paranasal folds
  • periocular
  • ears
  • scalp and temples
  • lips

Other factors

  • size > 2 cm
  • immunosuppression
  • genetic disorders such as Gorlin’s syndrome
  • previously treated lesion

Reference:

  1. NICE (February 2006).CSG Improving Outcomes for People with Skin Tumours including Melanoma: The Manual

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