Aetiology of phosphate deficiency
Causes include:
- reduced intake - chronic use of antacids such as aluminium hydroxide which causes excess binding of dietary phosphate
- increased loss:
- vitamin D resistant rickets - X-linked hypophosphataemia
- Fanconi's syndrome
- tumour induced - impaired renal conversion of 25(OH)D3 into calcitriol and phosphate wasting
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