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Results

Authoring team

Statins were clearly beneficial for patients with diabetes and for those high-risk non-diabetic patients enrolled in the study.

There were reductions in the event rate for first presentation of any major vascular events:

  • 22% reduction for treated diabetics (p<0.0001) vs. placebo-treated diabetics
  • there were similar reductions in the other high risk patients

Sub-group analysis demonstrated that:

  • diabetics who did not have overt vascular disease at entry into the trial had a highly significant 33% reduction in the event rate in simvastatin-treated vs. placebo-treated patients
  • diabetics with an LDL-cholesterol lower than 3.0 mmol/L (116 mg/dL) had a significant 27% reduction in the event rate in simvastatin-treated vs. placebo-treated patients
  • similar rate reductions were seen for diabetics with total cholesterol less than 5.0 mmol/L (193 mg/dL)

 

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