This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages without signing in

TCA components

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

During periods of low plasma glucose e.g. during starvation or exercise, any of the following substrates may become available to the liver:

  • fatty acids from lipolysis
  • lactate from anaerobic glycolysis
  • amino acids such as leucine and alanine

All can become incorporated into the tricarboxylic acid cycle to yield intermediate compounds. These intermediates limit glycolysis and so favour the reverse pathway of gluconeogenesis:

  • increased citric acid concentration decreases the activity of 6-phosphofructokinase
  • increased acetyl coenzyme A concentration decreases the activity of pyruvate dehydrogenase

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.