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Differential diagnosis

Authoring team

Several rare diseases may be mistaken for rickets on clinical, radiological or histological grounds. The differential includes:

  • hypophosphatasia - genetic deficiency of alkaline phosphatase with both autosomal recessive and dominant forms. The recessive disease presents as gross rickets and has a poor prognosis.
  • marble bone disease
  • chondrodysplasia - grossly disorganised growth plates resulting in severe bow legs. Osteotomies heal normally.
  • Blount's disease

Reference:

  • Chanchlani R. An Overview of Rickets in Children. Kidney Int Rep. 2020 Apr 11;5(7):980-990

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