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Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The majority of cases are idiopathic. However, there are a number of important associations including:

  • trisomies 13 and 18
  • Kallman's syndrome
  • holoprosencephaly
  • maternal drugs in pregnancy - in particular phenytoin
  • Pierre-Robin sequence
  • Goldenhar syndrome
  • EEC syndrome
  • there is an inherited element which is polygenic

Isolated cleft palate is commoner in females. However cleft palate associated with cleft lip is commoner in males.

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