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Coeliac disease and miscarriage

Authoring team

Up to 50% of women with untreated Coeliac disease (CD) refer an experience of miscarriage or an unfavorable outcome of pregnancy (1).

Gasbarrini, et al. (1) reported that 8% (3 out of 40 studied patients) of the CD prevalence in females with recurrent spontaneous abortions, defined as the presence of 2 or more consecutive spontaneous abortions of unknown origin.

In adult patients with CD, the disease has insidious clinical manifestations with few symptoms and the pregnancy may be considered a 'trigger' to unmask CD (2), that it may be considered as 'latent'.

 

Reference:

  • Gasbarrini A, Torre ES, Trivellini C, De Carolis S, Caruso A, Gasbarrini G. Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease. Lancet 2000; 356: 399- 400.
  • Collin P, Vilska S, Heinonen PK, Hallstrom O, Pikkarainen P. Infertility and celiac disease. Gut 1996; 39: 382-84

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