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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Common complications include:

  • weight loss
  • anaemia
  • arthritis - large joints
  • erythema nodosum
  • ocular problems - conjunctivitis, episcleritis, iritis
  • sacroiliitis - this is unrelated to HLA B27
  • gall stones, especially of the cholesterol type

Less common:

  • liver complications - primary sclerosing cholangitis, fatty liver, non-specific hepatitis, pericholangitis.
  • ankylosing spondylitis - related to HLA B27
  • pyoderma gangrenosum
  • carcinoma of the bile ducts and primary sclerosing cholangitis - much less common than in ulcerative colitis
  • renal complications - ureteric stricture, stones, right hydronephrosis, nephropathy (oxalate, amyloid).
  • nutritional deficiency - osteomalacia, weakness (potassium, magnesium, vitamin D), lassitude (vitamin B12, folate, iron), rashes (zinc, niacin), alteration of taste (zinc).
  • systemic amyloidosis - more common in Crohn's than UC
  • reduced fertility


  1. Jewell, D. Crohn's disease. Medicine International 1994;22:8: 321-6.

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