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Pathology

Authoring team

The pathogenesis of H. pylori-associated gastritis is characterised by:

  • predominant involvement of the antrum
  • characterised by presence of markers of chronic (mononuclear cells) and active (neutrophils) inflammation
  • intestinal metaplasia and atrophy:
    • predominantly in the antrum and corpus
    • as atrophy of the corpus progresses the gastric acid secretion reduces and the patient may become less symptomatic from any ulcer disease
    • the hypochlorhydric state is a risk factor for the development of gastric cancer
  • development of lymphatic tissue:
    • the normal gastric mucosa contains no lymphatic tissue - patients with chronic H. pylori infection have mucosa-associated lymphatic tissue.
    • there is evidence linking H. pylori gastritis with gastric lymphoma.

Reference

  1. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015 Sep;64(9):1353-67.

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