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Foetal haemoglobin

Authoring team

Various compounds e.g. hydroxycarbamide and butyrate derivatives, have been shown to stimulate the transcription of the fetal globin genes in patients with beta-thalassaemia:

  • disadvantages - at present it is unclear whether the extremely high blood concentrations required might have deleterious side effects if maintained for long periods.
  • important findings - proves that the fetal haemoglobin genes can be reactivated after birth.

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