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Methionine

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Methionine is a sulphur-containing amino acid in which the R group in the general formula NH2-CHR-COOH is the group -CH2-CH2-S-CH3. It is an essential amino acid.

Methionine can be minimally synthesized from homocysteine in conjunction with methylcobalamin.

Methionine can be further metabolized to:

  • formate, important for:
    • purine synthesis } required for DNA synthesis
    • thymidylate synthesis }
    • folate production
  • S-adenosylmethionine; important in neuronal metabolism

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