Increased formation of uric acid
Mechanisms:
- increased nucleic acid turnover:
- lymphoma
- psoriasis
- haemolysis
- myeloproliferative disease
- muscle necrosis
- enzyme deficiencies e.g. glucose-6-phosphatase
- increased production:
- Lesch-Nyhan syndrome
- von Gierke's disease
- high dietary purine intake e.g. sweetmeats, offal
- fructose infusion
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