Endocytosis
Following exocytosis, vesicular membrane and proteins are retrieved from the plasma membrane through endocytosis, which recycles vesicles, maintains exocytosis, and prevents secretory cells from swelling or shrinking.
Secretory cells employ three exocytosis modes - full-collapse fusion, kiss-and-run, and compound exocytosis - to control the rate and amount of vesicular content release and to thus control exocytosis strength and mediate plasticity of exocytosis, including synaptic plasticity.
These three exocytosis modes are followed by three endocytosis modes -classical endocytosis, kiss-and-run, and bulk endocytosis, respectively - that ensure sufficient vesicle recycling during different activities.
Reference
- Wu L et al. Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms. Annu Rev Physiol. 2013 Nov 20;76:301–331
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