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Prognosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Individuals heterozygous for familial hypercholesterolaemia (FH) experience an increased risk of coronary heart disease and death from myocardial infarction (MI) in middle life.

  • if left untreated, men and women with heterozygous FH with total cholesterol levels of 8-15 mmol/L (310-580 mg/dL) typically develop CHD before age 55 and 60, respectively, while homozygotes with total cholesterol levels of 12-30 mmol/L (460-1160 mg/dL) typically develop CHD very early in life and if untreated die before age 20
  • however, once diagnosed, heterozygotes can readily be treated with cholesterol-lowering medication to attenuate development of atherosclerosis and to prevent CHD

Reference:

  • Versmissen J, Oosterveer DM, Yazdanpanah M, Defesche JC, Basart DC, Liem AH, Heeringa J, Witteman JC, Lansberg PJ, Kastelein JJ, Sijbrands EJ . Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ 2008;337:a2423

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