This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages without signing in

Aggregation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Aggregation describes the accumulation of platelets in large numbers at the site of damage to form a haemostatic plug - the thrombus. It is the result of increased numbers of platelets arriving at the site, being rapidly activated, and interlinking via their pseudopodia.

Platelet activating factor, 5-HT, thrombin, ADP and thromboxane all contribute to the cascade. Initially, platelets are loosely bound by a fibrinogen cross-link; this is reinforced by thrombospondin.

Aggregation seems dependent on the close interaction of local arachidonic acid metabolites which aspirin modulates to therapeutic advantage.


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.