Side effects
The dose-limiting toxic effects vary with respect to different alkaloid, for example
- myelosuppression with vinblastine
- neurotoxicity with vincristine - sensorimotor peripheral neuropathy
Other side effects include:
- paralytic ileus
- alopecia
- joint pain
- inappropriate ADH secretion
The toxicity of these compounds may be potentiated in patients with obstructive jaundice.
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