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Predictive factors of severity in sickle cell disease (SCD)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The level to which SCD clinically manifests itself can vary significantly:

  • HbSS and HbS/ beta thalassaemia display greatest severity
  • severity of sickling depends on the percentage of haemoglobin present

Several genetic and environmental factors may affect the severity of sickling in an individual:

  • genetic factors
    • a higher than usual HbF level
    • coexisting thalassaemia
    • double heterozygosity (e.g. - HbSC)
    • other linked genetic polymorphism leading to severe or mild phenotypes
  • environmental factors - infection, climate, nutrition, psychosocial factors, socioeconomic status

Reference:

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