This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages without signing in

Front-loaded tPA regimen

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The GUSTO I study showed that accelerated administration of t-PA in association with intravenous heparin gives optimum results:

  • accelerated administration of t-PA:
    • intravenous bolus dose of 15 mg
    • followed by an infusion of 0.75 mg per kilogram of body weight over a 30-minute period (maximum 50 mg)
    • then an infusion of 0.5 mg per kg over a 60-minute period (maximum 35 mg)

  • intravenous heparin:
    • bolus dose of 5000 u
    • followed by a continuous infusion of 1000 u per hour

  • 300 mg of aspirin should be chewed, followed by 75-150 mg/day indefinitely

The accelerated tPA regimen should be considered in patients who:

  • are < 50 yr old
  • have large infarcts
  • present within 4 hr of the onset of symptoms
  • are normotensive (systolic b.p. < 140 mmHg)

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.