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Investigations

Authoring team

  • the FBC shows anaemia of variable severity (Hb 5-10 g/l)
  • the oxygen dissociation curve is displaced to the right as a result of the raised intracellular 2,3-diphosph- glycerate
  • the blood film shows prickle cells and reticulocytosis
  • autohaemolysis is increased and glucose is not protective in contrast to hereditary spherocytosis
  • pyruvate kinase is only 5-20% of normal levels

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