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Regulation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Pyruvate kinase is inhibited by:

  • ATP; hence, glycolysis is limited when the cell is energy-laden
  • glucagon, by secondary messenger-mediated phosphorylation; hence, when plasma glucose is low the rate of glycolysis is reduced as a means of conservation for tissues in which glucose is an obligatory fuel

It is stimulated by fructose-1,6-biphosphate, so providing feedforward regulation from earlier in the glycolytic pathway.

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