AIDS and malignant disease
HIV infection predisposes to the development of certain neoplasms, whose clinical course may differ from those seen in non-infected individuals.
It is associated with three AIDS defining malignancies - Kaposi’s sarcoma, high-grade B-cell non Hodgkin’s lymphoma and invasive cervical cancer and a number of other malignancies.
Kaposi's sarcoma and non-Hodgkin's lymphoma are examples of this, as in AIDS the course of these tumours tends to be more aggressive and these patients should only be managed in a centre with expertise in the management of these diseases (1).
The UK National Guidelines for HIV Testing 2008 has recommended that HIV screening should be done in all patients with lymphoma since both Hodgkin’s and non-Hodgkin’s lymphomas are linked with HIV infection (2).
Reference:
- (1) British HIV Association 2008. British HIV association guideline for HIV associated malignancies 2008
- (2) The Medical Foundation for AIDS & Sexual Health (MedFASH) 2008. HIV for non-HIV specialists, diagnosing the undiagnosed: A practical guide for healthcare professionals secondary care to support improved detection and diagnosis of HIV in the UK
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