the Jo-1 antigen is one of a series of transfer ribonucleic acid (tRNA) sythetases that can act as autoantigens - in this case histidyl tRNA sythetase
antibodies to Jo-1 correlate with disease activity in the polymyositis and dermatomyositis spectrum, especially with the presence of pulmonary interstitial disease
antibodies to Jo-1 are found less often in SLE and mixed connective tissue disorders
Jo-1 functions in the cytoplasm but was originally classified as an extractable nuclear antigen (ENA) - still remains part of the ENA group
Reference:
(1) Sherley-Dale A. Serum autoantibodies and connective tissue disorders. Dermatology in Practice (April 2008); 16(1).
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