Epidemiology

Invasive aspergillosis:

• mostly impacts the immunocompromised population, eg, people living with advanced stages of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), those with hematologic malignancies, prolonged neutropenia, long-term corticosteroid use, those on immunosuppression, and recipients of hematopoietic or solid organ transplants
• may occur following broad-spectrum antibiotic therapy
• is not uncommon: 4% of unselected patients dying in European tertiary referral centres have invasive aspergillosis at post-mortem
• is underdiagnosed: a third are diagnosed at death

Reference

1. Bassetti M, Bouza E. Invasive mould infections in the ICU setting: complexities and solutions. J Antimicrob Chemother. 2017 Mar 01;72(suppl_1):i39-i47.