A gold standard method for diagnosis of Ulcerative colitis is not currently available (1).
Diagnosis of ulcerative colitis is achieved through a combination of medical history, clinical evaluation and supported by the typical endoscopic and histological findings (1):
Initial laboratory investigation methods for patients with active disease at presentation include:
A number of autoantibodies especially perinuclear antineutrophil cytoplasmic antibodies (pANCA) have been identified in patients with UC. (approximately 50-60% of patients are found to be positive for pANCA). Due to the low sensitivity of pANCA for the diagnosis of UC it cannot be used as a diagnostic tool (1)
Reference:
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