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HBsAg antibody ( anti - HBsAg )

Authoring team

  • anti-HBsAg indicates clinical recovery and immunity to hepatitis B virus
  • anti-HBsAg may also occur (via passive transfer) after transfusion
  • this antibody is found in about 80% of patients after clinical cure
  • anti-HBsAg may take several weeks or months to appear following the disappearance of HBsAg
  • in fulminant hepatitis the anti-HBsAg is produced early and may co-exist with low antigen titre
  • in chronic carriers - no antibody is present but antigen titres are high
  • the presence of anti-HBsAg without HBsAg detectable signifies:
    • recovery from HBV infection
    • absence of infectivity
    • immunity from future HBV infection
    • the presence of anti-HBsAg can be used to show effectivity of immunisation programme

Reference

  1. Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014 Dec 06;384(9959):2053-63

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