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Parkinson's disease and anxiety

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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A third of Parkinson's disease (PD) patients suffer from an anxiety disorder at any time point (1)

  • can precede or follow PD motor symptoms
  • anxiety is associated with demographic, disease-related motor and non-motor features

Retrospective study (UK data) found risk of developing Parkinson’s disease (PD) was at least doubled in people with anxiety vs those without (2):

  • in those with anxiety, the presence of depression, hypotension, tremor, rigidity, balance impairment, constipation, sleep disturbance, fatigue, and cognitive impairment were associated with an increased risk of developing PD
    • clinical features of those who developed PD can help identify patients presenting with anxiety who are in the prodromal phase of PD

Reference:

  • Abou Kassm S, Naja W, Haddad R, Pelissolo A. The Relationship Between Anxiety Disorders and Parkinson's Disease: Clinical and Therapeutic Issues. Curr Psychiatry Rep. 2021 Mar 3;23(4):20. Baz0-Alvarez JC et al.
  • Risk of Parkinson’s disease in people with New Onset Anxiety over 50 years - Incidence and Associated Features. BJGP 21 March 2024 DOI: 10.3399/BJGP.2023.0423

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