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Cautions and contra-indications

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Sulphonylureas are contraindicated in those patients with known sulpha allergy and in pregnant women.

Care should also be taken in patients with renal impairment. Chlorpropamide in contraindicated since 20% is excreted unaltered in the urine whilst tolbutamide, glicazide and glipizide are relatively safe since their hepatic metabolites are inactive and only small quantities are excreted unaltered in the urine.

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