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Epidermal growth factor receptor (EGFR) and lung cancer

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Epidermal growth factor receptor (EGFR) function and its role in lung cancer

EGFR belongs to the erbB family of closely related receptor tyrosine kinases, which include erbB1 (also known as EGFR), erbB2 (HER2), erbB3, and erbB4

  • basic structures are similar for the erbB family
  • each of the erbB family has distinct properties, including variation in tyrosine kinase activity
  • in non-small cell lung cancer, overexpression of EGFR or mutations in intracellular EGFR have been observed in 43-89% of cases (5)

Reference:

  • Gupta R, Dastane AM, Forozan F, Riley-Portuguez A, Chung F, Lopategui J, et al. Evaluation of EGFR abnormalities in patients with pulmonary adenocarcinoma: the need to test neoplasms with more than one method. Mod Pathol. 2009;22:128-33.

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