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Lysosomal disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Lysosomes are subcellular organelles which are bounded by a single phospholipid bilayer membrane and contain one or more acid hydrolase enzyme.

Lysosome are involved in:

  • biosynthesis
  • exocytic pathways
  • endocytic pathways

Lysosomes are the site of metabolism of many macromolecules which are:

  • presented to the cell from the external environment
  • synthesized within the cell

Absence of an enzymic activity causes accumulation of precursor chemicals in the lysosome. It is often the pathological storage of material in lysosomes which causes organ damage.

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