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Van der Woude's syndrome

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Van der Woude syndrome is a rare inherited disorder that affects mouth formation in utero. Children with this condition have sunken or raised pits in their lower lip called lip pits. They may also have a cleft lip, a cleft palate, or both. Some of a child’s teeth might not develop.

Children with this syndrome inherit a changed or mutated interferon regulatory factor 6 gene (IRF6) from one parent.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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