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Amphetamine psychosis

Authoring team

Dextroamphetamine and methamphetamine have a high affinity for the monoamine transporter DAT, and intoxication can cause psychiatric disturbances resembling a manic episode or an acute psychotic break

Amphetamine psychosis is a syndrome of restlessness, elation, paranoid ideas and hallucinosis - i.e. a schizophreniform psychosis which occurs due to abuse of amphetamines.

Other illicit amphetamine analogues such as MDMA are potentially more likely to cause hyperthermia, serotonin syndrome, and rhabdomyolysis.

Reference

  1. Steinkellner T et al. The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine. Biol Chem. 2011 Jan;392(1-2):103-15.

 


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