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Plasma ADH in response to infusion of hypertonic saline

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This distinguishes cranial diabetes insipidus from primary polydipsia and nephrogenic diabetes insipidus:

  • CDI patients have low plasma ADH
  • NDI and PP patients show normal levels of plasma ADH

NDI patients may be distinguished by their high plasma ADH relative to urine osmolarity after a period of dehydration.

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