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Pathogenesis of atopic asthma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Atopic asthma is the result of airway inflammation caused by exposure to an environmental allergen.

Patients with asthma have an exuberant Th2-mediated IgE humoural immune response.

IgE binds to bronchial mast cells via the FcERI (high affinity receptor) resulting in degranulation and the release of pro-inflammatory mediators.

There are two phases of inflammation:

  • acute phase
  • delayed phase

The results of inflammation are:

  • bronchial hyper-reactivity
  • symptoms of cough, wheeze and chest tightness
  • signs of variable polyphonic wheezes

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