Monoamine oxidase inhibitors (anaesthesia management)
MAOI's have two salient interactions which makes their use dangerous in general anaesthesia:
- exaggerated response to exogenous catecholamines
- inhibition of metabolism of pethidine; respiratory depression, hypotension or hypertension may result
Hence, all MAOI's (type A and B) should be stopped at least three weeks before surgery.
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