Aspirin is the most common salicylate in regular use and poisoning is common. In adults, moderate to severe toxicity may occur after taking 50 x 300 mg tablets.
Salicylates may also be found in:
Normally aspirin is rapidly absorbed from the stomach and the small intestine but in large doses, clearance and absorption may be slowed as the tablets adhere to form a large bolus. Blood salicylate levels may continue to rise for up to 24 hours after a massive overdose.
Toxicity occurs above 250 mg per litre.
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