Sickle cell crises occur most commonly in haemoglobin S homozygotes. Patients with mixed haemoglobinopathies may have sickling episodes e.g. SC disease.
Sickle cell crises do not occur in Hb S heterozygotes.
Most common sites of pain onset are the back or trunk, and pain may then radiate to the limbs (1):
* acute chest syndrome
The various sickle cell crises and their acute management are described below.
Reference:
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