Glitazone therapy in the secondary prevention of stroke (and TIA)

Glitazones and prevention of recurrent strokes/TIAs (1):

• a systematic review concluded that "..Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-gammaagonists in the secondary prevention of stroke and related vascular events in people with stroke or TIA. .."

Reference:

1. Liu J, Wang LN.Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack. Cochrane Database Syst Reviews 08 October 2019.