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Treatment of cardiovascular syphilis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Procaine penicillin 600 mg/day i.m. for 21 days

Special care should be taken because a severe Jarisch-Herxheimer reaction may occur. This causes a fever, tachycardia and may weaken the aortic wall. If the coronary ostia are involved myocardial infarction may occur.

To reduce the severity of this reaction the patient should be placed on prednisolone.

Please check BNF and summary of product characteristics before prescribing drugs described.


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