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Diagnosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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This is made by assaying protease inhibitor activity, and typing proteins with isoelectric focusing.

Prenatal diagnosis is possible using oligonucleotide probes or intragenic restriction fragment length polymorphisms - RFLP's - to analyse DNA.

Levels of alpha1-antitrypsin are increased in all people in trauma, acute infections and pregnancy. This may bring levels of alpha-1 antitrypsin into the normal range in those with deficiency, and so delay diagnosis.


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